| dc.contributor.author | Serdar, Burmaoglu | |
| dc.contributor.author | Ali O., Yilmaz | |
| dc.contributor.author | Taslimi, Parham | |
| dc.contributor.author | Oztekin, Algul | |
| dc.contributor.author | Deryanur, Kilic | |
| dc.contributor.author | Ilhami, Gulcin | |
| dc.date.accessioned | 2019-05-07T13:38:15Z | |
| dc.date.available | 2019-05-07T13:38:15Z | |
| dc.date.issued | 2018-02 | |
| dc.identifier.uri | http://hdl.handle.net/11772/1178 | |
| dc.description.abstract | A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.isversionof | 10.1002/ardp.201700314 | en_US |
| dc.rights | info:eu-repo/semantics/restrictedAccess | en_US |
| dc.subject | -glycosidase | en_US |
| dc.subject | Acetylcholinesterase | en_US |
| dc.subject | Butyrylcholinesterase | en_US |
| dc.subject | Carbonic anhydrase | en_US |
| dc.subject | Phloroglucinol derivatives | en_US |
| dc.title | Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Archiv der Pharmazie | en_US |
| dc.contributor.department | Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü | en_US |
| dc.identifier.volume | 351 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | e1700314 | en_US |
