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dc.contributor.authorSerdar, Burmaoglu
dc.contributor.authorAli O., Yilmaz
dc.contributor.authorTaslimi, Parham
dc.contributor.authorOztekin, Algul
dc.contributor.authorDeryanur, Kilic
dc.contributor.authorIlhami, Gulcin
dc.date.accessioned2019-05-07T13:38:15Z
dc.date.available2019-05-07T13:38:15Z
dc.date.issued2018-02
dc.identifier.urihttp://hdl.handle.net/11772/1178
dc.description.abstractA series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ardp.201700314en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subject-glycosidaseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectPhloroglucinol derivativesen_US
dc.titleSynthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activityen_US
dc.typearticleen_US
dc.relation.journalArchiv der Pharmazieen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume351en_US
dc.identifier.issue2en_US
dc.identifier.startpagee1700314en_US


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