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dc.contributor.authorParham, Taslimi
dc.contributor.authorAfsun, Sujayev
dc.contributor.authorFikret, Turkan
dc.contributor.authorEmin, Garibov
dc.contributor.authorZubeyir, Huyut
dc.contributor.authorVagif, Farzaliyev
dc.contributor.authorSevgi, Mamedova
dc.contributor.authorIlhami, Gulcin
dc.date.accessioned2019-05-07T13:53:02Z
dc.date.available2019-05-07T13:53:02Z
dc.date.issued2018-02
dc.identifier.urihttp://hdl.handle.net/11772/1180
dc.description.abstractThe conversion reactions of pyrimidine-thiones with nucleophilic reagent were studied during this scientific research. For this purpose, new compounds were synthesized by the interaction between 1,2-epoxy propane, 1,2-epoxy butane, and 4-chlor-1-butanol and pyrimidine-thiones. These pyrimidine-thiones derivatives (A-K) showed good inhibitory action against acetylcholinesterase (AChE), and human carbonic anhydrase (hCA) isoforms I and II. AChE inhibition was in the range of 93.1 +/- 33.7-467.5 +/- 126.9nM. The hCA I and II were effectively inhibited by these compounds, with K-i values in the range of 4.3 +/- 1.1-9.1 +/- 2.7nM for hCA I and 4.2 +/- 1.1-14.1 +/- 4.4nM for hCA II. On the other hand, acetazolamide clinically used as CA inhibitor showed K-i value of 13.9 +/- 5.1nM against hCA I and 18.1 +/- 8.5nM against hCA II. The antioxidant activity of the pyrimidine-thiones derivatives (A-K) was investigated by using different in vitro antioxidant assays, including Cu(2+)and Fe(3+)reducing, 1,1-diphenyl-2-picrylhydrazyl (DPPH center dot) radical scavenging, and Fe(2+)chelating activities.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.22019en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAntioxidant activityen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPyrimidine-thionesen_US
dc.titleSynthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activitiesen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume32en_US
dc.identifier.issue2en_US
dc.identifier.startpagee22019en_US


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