Show simple item record

dc.contributor.authorFatos, Erdemir
dc.contributor.authorDuygu Barut, Celepci
dc.contributor.authorAydin, Aktas
dc.contributor.authorParham, Taslimi
dc.contributor.authorYetkin, Gok
dc.contributor.authorHasan, Karabiyik
dc.contributor.authorIlhami, Gulcin
dc.date.accessioned2019-05-07T13:57:54Z
dc.date.available2019-05-07T13:57:54Z
dc.date.issued2018-03-05
dc.identifier.urihttp://hdl.handle.net/11772/1182
dc.description.abstractThis study contains novel a serie synthesis of N-heterocyclic carbene (NHC) precursors that 2-hydroxyethyl substituted. The NHC precursors have been prepared from 1-(2-hydroxyethyl)benzimidazole and alkyl halides. The novel NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy and elemental analysis techniques. Molecular and crystal structures of 2a, 2d, 2e, 2f and 2g were obtained with single-crystal X-ray diffraction studies. These novel NHC precursor's derivatives effectively inhibited the a-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Inhibition constant (K-i) were found in the range of 0.30-9.22 nM for alpha-glycosidase, 13.90-41.46 nM for hCA I, 12.82-49.95 nM for hCA II, 145.82-882.01 nM for BChE, and 280.92-1370.01 nM for AChE, respectively. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectN-heterocyclic carbenesen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectCholinesteraseen_US
dc.subjectalpha-Glycosidaseen_US
dc.subjectX-ray diffractionen_US
dc.title2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory propertiesen_US
dc.typearticleen_US
dc.relation.journalJournal Of Molecular Structureen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume1155en_US
dc.identifier.startpage797en_US
dc.identifier.endpage806en_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record