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dc.contributor.authorAydin, Aktas
dc.contributor.authorTaslimi, Parham
dc.contributor.authorIlhami, Gulcin
dc.contributor.authorYetkin, Gok
dc.date.accessioned2019-05-17T07:50:45Z
dc.date.available2019-05-17T07:50:45Z
dc.date.issued2017-06
dc.identifier.urihttp://hdl.handle.net/11772/1192
dc.description.abstractThree series of imidazolidinium ligands (NHC precursors) substituted with 4-vinylbenzyl, 2-methyl-1,4-benzodioxane, and N-propylphthalimide were synthesized. N-Heterocyclic carbene (NHC) precursors were prepared from N-alkylimidazoline and alkyl halides. The novel NHC precursors were characterized by H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. The enzymes inhibition activities of the NHC precursors were investigated against the cytosolic human carbonic anhydrase I and II isoenzymes (hCA I and II) and the acetylcholinesterase (AChE) enzyme. The inhibition parameters (IC50 and K-i values) were calculated by spectrophotometric method. The inhibition constants (K-i) were found to be in the range of 166.65-635.38nM for hCA I, 78.79-246.17nM for hCA II, and 23.42-62.04nM for AChE. Also, the inhibitory effects of the novel synthesized NHCs were compared to acetazolamide as a clinical CA isoenzymes inhibitor and tacrine as a clinical cholinergic enzymes inhibitor.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ardp.201700045en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectEnzyme purificationen_US
dc.subjectN-Heterocyclic carbenesen_US
dc.titleNovel NHC precursors: synthesis, characterization, and carbonic anhydrase and acetylcholinesterase inhibitory propertiesen_US
dc.typearticleen_US
dc.relation.journalArchiv der Pharmazieen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume350en_US
dc.identifier.issue6en_US
dc.identifier.startpagee1700045en_US


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