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dc.contributor.authorTaslimi, Parham
dc.contributor.authorAkıncıoğlu, Hülya
dc.contributor.authorİlhami, Gülçin
dc.date.accessioned2019-05-17T08:25:32Z
dc.date.available2019-05-17T08:25:32Z
dc.date.issued2017-11
dc.identifier.urihttp://hdl.handle.net/11772/1199
dc.description.abstractIn this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, -amylase, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine and phenylephrine had K-i values of 199.02 +/- 16.01 and 65.01 +/- 5.00M against hCA I and 336.02 +/- 74.01 and 92.04 +/- 18.03M against hCA II, respectively. On the other hand, their K-i values were found to be 169.10 +/- 80.03 and 88.03 +/- 5.01nM against AChE and 177.06 +/- 6.01 and 78.03 +/- 3.05nM against BChE, respectively. -Amylase and -glycosidase enzymes were easily inhibited by these compounds. -Glycosidase inhibitors, generally defined to as starch blockers, are anti-diabetic drugs that help to decrease post comestible blood glucose levels.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.21973en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAlpha-amylaseen_US
dc.subjectAlpha-glycosidaseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectPhenylephrineen_US
dc.subjectSynephrineen_US
dc.titleSynephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitorsen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.issue11en_US
dc.identifier.startpagee21973en_US


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