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dc.contributor.authorGul, Halise Inci
dc.contributor.authorKucukoglu, Kaan
dc.contributor.authorYamali, Cem
dc.contributor.authorBilginer, Sinan
dc.contributor.authorYuca, Hafize
dc.contributor.authorOzturk, Iknur
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2019-06-13T06:26:53Z
dc.date.available2019-06-13T06:26:53Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/11772/1384
dc.description.abstractIn this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by H-1 NMR, (CNMR)-C-13, and HRMS. Ketones used were: Acetophenone (S1), 4-methylacetophenone (S2), 4-chloroacetophenone (S3), 4-fluoroacetophenone (S4), 4-bromoacetophenone (S5), 4-methoxyacetophenone (S6), 4-nitroacetophenone (S7), 2-acetylthiophene (S8), 2-acetylfuran (S9), 1-indanone (S10), 2-indanone (S11). The compounds S9, S10 and S11 were reported for the first time, while S1-S8 was synthesized by different method than literature reported using microwave irradiation method instead of conventional heating in this study. The inhibitory effects of 4-(2-substituted hydrazinyl) benzenesulfonamide derivatives (S1-S11) against hCA I and II were studied. Cytosolic hCA I and II isoenzymes were potently inhibited by new synthesized sulphonamide derivatives with K-is in the range of 1.79 +/- 0.22-2.73 +/- 0.08 nM against hCA I and in the range of 1.72 +/- 0.58-11.64 +/- 5.21nM against hCA II, respectively.en_US
dc.language.isoengen_US
dc.publisherInformaen_US
dc.relation.isversionof10.3109/14756366.2015.1047359en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subject2-Acethylfuranen_US
dc.subject2-acethylthiopheneen_US
dc.subjectAcetophenonesen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectIndanoneen_US
dc.subjectSulfonamideen_US
dc.titleSynthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effectsen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.issue4en_US
dc.identifier.startpage568en_US
dc.identifier.endpage573en_US


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