Biyoteknoloji Bölümü
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Biyoteknoloji Bölümü Diğer Yayınlar Koleksiyonu [25]
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Biyoteknoloji Bölümü Makale Koleksiyonu [91]
Biyoteknoloji Bölümü'ne ait makale çalışmalarını içerir
Recent Submissions
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Production of red fluorescent protein (mCherry) in an inducible E. coli expression system in a bioreactor, purification and characterization
(International Advanced Researches And Engineering Journal, 2018-06-01)New and improved genetic engineered variants of fluorescent proteins (FPs) have become useful tools for bioimaging in biomedical researches. Red fluorescent proteins (RFPs) first derived from the sea anemone Discosoma show ... -
Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase
(Informa, 2016)2-(Methacryloyloxy)ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate, is a cyclic urea derivative synthesized from urea, 2-(methacryloyloxy) ethyl acetoacetate and substituted benzaldehyde, and tested ... -
Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
(Informa, 2016)The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl (P2)/N-methylpiperazin-1-yl (P3)]methyl)-1H-indole-2,3-dione) moieties against human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoenzymes ... -
The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives
(Informa, 2016-01)Carbonic anhydrases (CAs, EC 4.2.1.1) had six genetically distinct families described to date in various organisms. There are 16 known CA isoforms in humans. Human CA isoenzymes I and II (hCA I and hCA II) are ubiquitous ... -
The synthesis of some beta-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles
(Informa, 2016-12)beta-Lactam antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contain a beta-lactam ring in their molecular structures. Synthesis of beta-lactam analogs, which are containing dichloride ... -
Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
(Informa, 2016-12)A series of diaryl ethers were synthesized and their human (h) carbonic anhydrase (CA) isoenzymes hCA I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory actions were investigated. The new ... -
Removal of some textile dyes from aqueous solution by using a catalase-peroxidase from aeribacillus pallidus (P26)
(Oriental Scientific Pub. Co., 2013-12)The textile dyeing wastewater is discharged to the environment in various occasions and causes severe environmental problems. Therefore, more effective treatment methods should be developed to eliminate dyes from the ... -
Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives
(Elsevier, 2015-06)In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions ... -
The effects of some bromophenols on human carbonic anhydrase isoenzymes
(Informa, 2016)Carbonic anhydrases (CAs, EC 4.2.1.1), which are involved in a variety of physiological and pathological processes, are ubiquitous metalloenzymes mainly catalyzing the reversible hydration of carbon dioxide (CO2) to ... -
Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects
(Informa, 2016)In this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by H-1 NMR, (CNMR)-C-13, and HRMS. Ketones used were: Acetophenone (S1), ... -
Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides
(Informa, 2016)A series of new 4-(3-(4-substitutedphenyl)-3a, 4-dihydro-3H-indeno[1,2-c] pyrazol-2-yl) benzenesulfonamides (7-12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1-6) and ... -
In vivo effects of o-coumaric acid on rat liver flavin-containing monooxygenase (fmo) activity and expression
(2012-06-29)Phenolic compounds are biologically active molecules and suggested to have some disease-preventive properties such as cardiovascular and certain types of cancer. Coumaric acid has been known as a phenolic compound and found ... -
Effects of medicinal plant viscum album l. on rat liver flavin-containing monooxygenase activity and expression
(2012-06-21)Viscum album L., a species of mistletoe, contains lectins, polypeptides, mucilage, sugar alcohols, flavonoids, lignans, triterpenes, and phenylallyl alcohols1. The leaves and twigs of Viscum album L., taken as tea, have ... -
Tannik asidin tavşan karaciğerinde flavin monooksijenaz, sitokrom p450 ve antioksidan enzim aktiviteleri üzerine in vitro etkileri
(2010-06-25)Giriş: Bu çalışmada bitki fenolik bileşiklerinden tannik asidin ilaçlar ve çeşitli kimyasal bileşiklerin metabolizmasında rol alan enzimler ile antioksidan enzim sistemleri üzerine in vitro etkileri incelenmiştir. Gereç ... -
Civa ve gümüşün sıçan karaciğer nad(p)h:kuinon oksidoredüktaz 1 enzimi üzerine in vitro etkileri
(Türk Biyokimya Derneği, 2011-12-02)Kirlenmiş toprak ve sularda bulunan ağır metallerin sağlığa zararlı olduğu bilinmektedir. Bu çalışmada, civa ve gümüşün ksenobiyotik kuinonların detoksifikasyonunda rol alan ve antioksidan olarak da görev yapabilen ... -
Sıçan karaciğer flavin monooksijenaz (fmo) enziminin aktivite ve protein ekspresyonunun elajik asit tarafından değişimi
(Türk Toksikoloji Derneği, 2012-11-18)Flavin monooksijenazlar (FMO) FAD içeren endoplazmik retikuluma ve de çekirdek zarına yapışık bulunan ve ksenobiyotik metabolizmasında rol alan Faz I enzimleridir. FMO’lar NADPH’ı kofaktör olarak kullanarak çok çeşitli ... -
Synthesis and carbonic anhydrase inhibition of tetrabromo chalcone derivatives
(Wiley, 2017-12)In the present study, human carbonic anhydrase (hCA) enzyme was purified and characterized from fresh blood human red cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity gel chromatography. Secondly, a series of new ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
(Wiley, 2017-11)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats
(Wiley, 2017-11)The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase ... -
Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors
(Wiley, 2017-11)In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, -amylase, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase ...
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