Fen Fakültesi: Recent submissions
Now showing items 321-340 of 411
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Meta-Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, -glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties
(Wiley, 2018-07)meta-Cyanobenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by the reaction of a series of N-(alkyl)benzimidazolium with 3-bromomethyl-benzonitrile. These benzimidazolium salts were characterized ... -
Novel benzylic substituted imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts: potent carbonic anhydrase and acetylcholinesterase inhibitors
(2018-07-23)The new imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts were synthesized in good yield by the reaction of the corresponding N,N'-dialkylalkanediamine with triethyl orthoformate in the presence of ... -
Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
(Wiley, 2018-08)In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ... -
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
(Bioorganic Chemistry, 2019-04)Starting from vanillin, known four benzyl bromides with Br were synthesized. The first synthesis of natural product 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol (2) and 3,4,6-tribromo-5-((methylsulfonyl) ... -
Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes
(Gulcin, I; Celik, M, 2018-08)In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f). carbonyl sulfonamides (3h and i). and carbonyl sulfamates (4h and 4i), which were tested against two ... -
Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones
(MONATSHEFTE FUR CHEMIE, 2019-04)A series of novel 1,3,5-trisubstituted pyrazoline derivatives, (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones, were ... -
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
(Bioorganic Chemistry, 2019-02-04)Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, ... -
Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases
(Bioorganic Chemistry, 2019-01-24)Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the ... -
Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties
(POLYHEDRON, 2019-02-01)This study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a-i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation ... -
Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes
(Bioorganic Chemistry, 2019-03)A new coordination polymer Zn(II) with thiosemicarbazone glyoxalic acid H(2)GAT was obtained in this study. According to the X-ray diffraction data, the coordination of the Zn(II) ion is carried out by one sulfur atom, in ... -
Sanal öğrenme topluluğundaki öğrencilerin bilgi paylaşma davranışlarına etki eden faktörlerin incelenmesi
(2017)Bu araştırmanın amacı sanal öğrenme topluluğundaki öğrencilerin bilgi paylaşma davranış eğilimlerine etki eden faktörleri incelemektir. Araştırmanın katılımcılarını, harmanlanmış öğrenme yöntemi ile yürütülen Bilgisayar I ... -
Problems experienced in evaluating success and performance in distance education: a case study
(2017)Uzaktan Eğitimde Başarı ve Performansın Değerlendirilmesinde Karşılaşılan Sorunlar: Bir Durum Çalışması Değişen sosyal koşullara ayak uydurmak, bireylerin öğrenme ihtiyaçlarını karşılamak ve hayat boyu öğrenenler olmasını ... -
Examining secondary school students’ safe computer and ınternet usage awareness: an example from Bartın province
(2017)Information and Communication Technologies (ICT) have been rapidly prevailed among the children and youths. Personal technologies facilitating the students to gain some learning experiences both in and out of the schools ... -
Lise öğrencilerinin güvenli bilgisayar ve internet kullanım farkındalıklarının incelenmesi: bartın ili örneği
(2017)Information and Communication Technologies (ICT) have been rapidly prevailed among the children and youths. Personal technologies facilitating the students to gain some learning experiences both in and out of the schools ... -
Çevrimiçi ve geleneksel yüz yüze hizmet içi eğitim uygulamalarının karşılaştırılması: deneysel bir çalışma
(2017)Bu araştırmanın amacı öğretmenlere yönelik yüz yüze ve çevrimiçi uzaktan eğitim yöntemiyle verilecek bir hizmet içi eğitim sürecini gerçekleştirmek ve bu eğitimin etkisini bilgisayar okuryazarlığı boyutunda değerlendirmektir. ... -
Comparison of online and traditional face-to-face in-service training practices: an experimental study
(2017)The purpose of this study is to carry out the process of conducting an in-service education process via face-to-face and online distance education methods and to evaluate the impact of this ... -
Öğretmenlerin yaşam boyu öğrenme eğilimlerinin incelenmesi
(2017)Yaşam boyu öğrenme, gerek bilgi ve iletişim teknolojilerindeki (BİT) gelişmeler ve bunların eğitime yansıması, gerekse de pedagojik uygulamalardaki yenilikler gereği öğretmenlerin mesleki gelişimlerini sürdürmeleri noktasında ... -
Öğretmenlerin eğitsel internet kullanım öz-yeterlik inançlarının yaşam boyu öğrenme bağlamında incelenmesi
(2017)Yaşam boyu öğrenme, eğitim sistemlerinde yaşanan değişimlerle birlikte öğretmenlerin bu değişimlere uyum sağlayabilmeleri, mesleki gelişimlerini devam ettirebilmeleri noktasında önemli bir yeterlik olarak karşımıza ... -
Derste etkileşimli tahta kullanımına yönelik tutum ile derse etkin katılım arasındaki ilişkinin incelenmesi
(2017)FATİH Projesi olarak bilinen Fırsatları Artırma ve Teknolojiyi İyileştirme Hareketi Projesi kapsamında Milli Eğitim Bakanlığına bağlı okullarda donanımsal anlamda yeni teknolojiler sınıf ortamlarına entegre edilmeye ... -
Examining the relationship between pre-service teachers’ educational technology and material development competency and their techno-pedagogical competency
(2017)Although digital technologies signify innovation and prestige, adopting such technology in teaching praxis requires deeperunderstanding and examination of technology integration with different variables. This study examines ...
