Yazar "Taslimi, Parham" için Biyoteknoloji Bölümü Makale Koleksiyonu listeleme
Toplam kayıt 76, listelenen: 21-40
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In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4‐dihydro‐3H‐1,2, 4‐triazole‐3‐thiones—Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles
Timur, İrfan; Kocyigit, Ümit M.; Dastan, Taner; Sandal, Süleyman; Ceribası, Ali Osman; Taslimi, Parham; Gulcin, İlhami; Koparir, Metin; Karatepe, Mustafa; Çiftç, Mehmet (Wiley, 2019-01)The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti-inflammatory, antitumoural, cytotoxic, and antioxidant properties. In this study, a ... -
Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
Ozgun, Dilan Ozmen; Yamali, Cem; Gul, Halise Inci; Taslimi, Parham; Gulcin, Ilhami; Yanik, Telat; Supuran, Claudiu T. (Informa, 2016)The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl (P2)/N-methylpiperazin-1-yl (P3)]methyl)-1H-indole-2,3-dione) moieties against human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoenzymes ... -
Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats
Ilhami, Gulcin,; Taslimi, Parham; Koçyiğit, Ümit M.; Taşkıran, Ahmet Şevki; Yokus, Ahmet; Temel, Yusuf (Wiley, 2017-11)The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase ... -
The Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey
Umit M., Kocyigit; Sevgi Durna, Dastan; Taslimi, Parham; Taner, Dastan; Ilhami, Gulcin (Wiley, 2018-01)In this study, carbonic anhydrase (CA) enzyme was purified and characterized from blood samples of Kangal Akkaraman sheep and inhibitory properties on certain antibiotics were examined. CA purification was composed of ... -
Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes
Atmaca, Ufuk; Yıldırım, Alper; Taslimi, Parham; Çelik, Seda Tuncel; Gülçin, İlhami; Supuran, Claudiu T.; Çelik, Murat (Gulcin, I; Celik, M, 2018-08)In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f). carbonyl sulfonamides (3h and i). and carbonyl sulfamates (4h and 4i), which were tested against two ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Ilhami, Gulcin; Taslimi, Parham; Dastan, Taner; Koçyiğit, Ümit M.; Dastan, Sevgi Durna; Kılıçkaya, Pakize Cantürk; Çevik, Özge; Koparır, Metin; Orek, Cahit; Çetin, Ahmet (Wiley, 2017-11)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
Kucukoglu, Kaan; Gul, Halise Inci; Taslimi, Parham; Gulcin, Ilhami; Supuran, Claudiu T. (Bioorganic Chemistry, 2019-02-04)Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, ... -
Meta-Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, -glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties
Turker, Ferhat; Celepci, Duygu Barut; Celepci, Duygu Barut; Aktaş, Aydın; Taslimi, Parham; Gök, Yetkin; Aygün, Muhittin; Gülçin, İlhami (Wiley, 2018-07)meta-Cyanobenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by the reaction of a series of N-(alkyl)benzimidazolium with 3-bromomethyl-benzonitrile. These benzimidazolium salts were characterized ... -
Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases
Kuzu, Burak; Tan, Meltem; Taslimi, Parham; Gülçin, İlhami; Taşpınar, Mehmet; Menges, Nurettin (Bioorganic Chemistry, 2019-01-24)Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the ... -
Multiple studies have been recorded on the synthesis and design of multi‐aim anti‐Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer’s disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α‐glycosidase, α‐amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against α‐glycosidase and 3.3 nM against α‐amylase, respectively. In contrast, Ki values were found of 50.96 ± 2.18 μM against AChE and 53.17 ± 4.47 μM against BChE. α‐Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.
Kaya, Ruya; Taslimi, Parham; Naldan, Muhammet Emin; Gulçin, İlhami (Bentham Science, 2019)Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and ... -
Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties
Taslimi, Parham; Osmanova, Sabiya; Caglayan, Cuneyt; Turkan, Fikret; Sardarova, Sabira; Farzaliyev, Vagif; Sujayev, Afsun; Sadeghian, Nastaran; Gulçin, İlhami (Wiley, 2018-09)The thiolation reaction was carried out in a benzene solution at 80 degrees C and p-substituted ketones and mercaptoacetic acid in a molar ratio (1:4) of in the presence of a catalytic amount of toluene sulfonic acids. The ... -
Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
Ilhami, Gulcin; Taslimi, Parham; Öztaşkın, Necla; Göksu, Süleyman; Maraş, Ahmet (Elsevier, 2017-10)In this study, a series of novel bromophenols were synthesized from benzoic acids and methoxylated bromophenols. The synthesized compounds were evaluated by using different bioanalytical antioxidant assays including ... -
Novel benzylic substituted imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts: potent carbonic anhydrase and acetylcholinesterase inhibitors
Yigit, Beyhan; Yigit, Murat; Celepci, Duygu Barut; Gok, Yetkin; Aktas, Aydin; Aygun, Muhittin; Taslimi, Parham; Gulcin, Ilhami Ilhami (2018-07-23)The new imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts were synthesized in good yield by the reaction of the corresponding N,N'-dialkylalkanediamine with triethyl orthoformate in the presence of ... -
Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials
Genç Bilgiçli, Hayriye; Kestane, Ali; Taslimi, Parham; Karabay, Oguz; Bytyqi-Damoni, Arlinda; Zengin, Mustafa; Gulçin, İlhami (Elsevier, 2019-04-16)Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia ... -
Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties
Aktaş, Aydın; Celepci, Duygu Barut; Kaya, Ruya; Taslimi, Parham; Gök, Yetkin; Aygün, Muhittin; Gülçin, İlhami (POLYHEDRON, 2019-02-01)This study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a-i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation ... -
Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes
Yakup, Sari; Aydin, Aktas; Taslimi, Parham; Yetkin, Gok,; Ilhami, Gulcin (Wiley, 2018-01)The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted ... -
Novel NHC precursors: synthesis, characterization, and carbonic anhydrase and acetylcholinesterase inhibitory properties
Aydin, Aktas; Taslimi, Parham; Ilhami, Gulcin; Yetkin, Gok (Wiley, 2017-06)Three series of imidazolidinium ligands (NHC precursors) substituted with 4-vinylbenzyl, 2-methyl-1,4-benzodioxane, and N-propylphthalimide were synthesized. N-Heterocyclic carbene (NHC) precursors were prepared from ... -
Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties
Daryadel, Shahla; Atmaca, Ufuk; Taslimi, Parham; Gülçin, İlhami; Çelik, Murat (Wiley, 2018-11)Sulfamates have a large spectrum of biological activities including enzyme inhibition. Eight sulfamates derived from menthol (2a-h) were synthesized. Also, in the other section of this study, novel sulfamate derivatives ... -
Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors – Their antidiabetic, anticholinergic and antibacterial potentials
Zengin, Mustafa; Genc, Hayriye; Taslimi, Parham; Kestane, Ali; Guclu, Ertugrul (Elsevier, 2018-12)A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P. aeruginosa, E. coli and S. aureus strains ... -
Phytochemical content, antioxidant activity, and enzyme inhibition effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α‐amylase, butyrylcholinesterase, and α‐glycosidase enzymes
Bursal, Ercan; Aras, Abdulmelik; Kılıç, Ömer; Taslimi, Parham; Gören, Ahmet C.; Gülçin, İlhami (Journal Of Food Biochemistry, 2019-03)Many taxa of Salvia genus have been used in herbal beverages, food flavoring, cosmetics, and pharmaceutical industry. In this paper, chemical compounds of Salvia eriophora (S. eriophora) leaves were determined by LC-MS/MS ...