Yazar "Ilhami, Gulcin" için Biyoteknoloji Bölümü Makale Koleksiyonu listeleme
Toplam kayıt 30, listelenen: 1-20
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2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties
Fatos, Erdemir; Duygu Barut, Celepci; Aydin, Aktas; Parham, Taslimi; Yetkin, Gok; Hasan, Karabiyik; Ilhami, Gulcin (Elsevier, 2018-03-05)This study contains novel a serie synthesis of N-heterocyclic carbene (NHC) precursors that 2-hydroxyethyl substituted. The NHC precursors have been prepared from 1-(2-hydroxyethyl)benzimidazole and alkyl halides. The novel ... -
Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes
Parham, Taslimi; Ilhami, Gulcin (Wiley, 2017-10)-Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as -glycosidase and -amylase ... -
Antioxidant activity, acetylcholinesterase, and carbonic anhydrase inhibitory properties of novel ureas derived from phenethylamines
Kadir, Aksu; Bunyamin, Ozgeris; Taslimi, Parham; Ali, Naderi; Ilhami, Gulcin; Suleyman, Goksu (Wiley, 2016-12)A series of ureas derived from phenethylamines were synthesized and evaluated for human carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzyme inhibitory activities and ... -
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base
Parham, Taslimi; Sabiya, Osmanova; Ilhami, Gulcin; Sabira, Sardarova; Vagif, Farzaliyev; Afsun, Sujayev; Ruya, Kaya; Fatma, Koc; Sukru, Beydemir; Saleh H., Alwasel; Omer Irfan, Kufrevioglu (Wiley, 2017-09)Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ... -
The effects of wireless electromagnetic fields on the activities of carbonic anhydrase and acetylcholinesterase enzymes in various tissues of rats
Umit Muhammet, Kocyigit,; Taslimi, Parham; Fatih, Gurses; Sinan, Soylu; Sevgi Durna, Dastan; Ilhami, Gulcin (Wiley, 2018-03)The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For ... -
Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes
Umit M., Kocyigit; Taslimi, Parham; Hayreddin, Gezegen; Ilhami, Gulcin; Mustafa, Ceylan (Wiley, 2017-09)Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ... -
The first synthesis and antioxidant and anticholinergic activities of 1-(4,5-dihydroxybenzyl)pyrrolidin-2-one derivative bromophenols including natural products
Mohsen, Rezai; Cetin, Bayrak; Taslimi, Parham; Ilhami, Gulcin; Abdullah, Menzek (Turkish Journal of Chemistry, 2018)We report herein the first synthesis of biologically active natural bromophenols, namely 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)pyrrolidin-2-one (2), 2RS-1- (2 ,3-dibromo-4 ,5-dihydroxybenz yl)-5-oxopyrrolidine-2-carboxylic ... -
The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes
Cetin, Bayrak; Taslimi, Parham; Ilhami, Gulcin; Abdullah, Menzek (Elsevier, 2017-06)The first synthesis of (E)-4-(3-bromo-4,5-dihydroxyphenyl) but-3-en-2-one (1), (E)-4-(2-bromo-4,5-dihy droxyphenyl) but-3-en-2-one (2), and (E)-4-(2,3-dibromo-4,5-dihydroxyphenyl) but-3-en-2-one (3) was realized as natural ... -
The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study
Taslimi, Parham; Cuneyt, Caglayan; Ilhami, Gulcin (Wiley, 2017-12)Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, ... -
The in vivo effects of cefazolin, cefuroxime, and cefoperazon on the carbonic anhydrase in different rat tissues
Fikret, Turkan; Zubeyir, Huyut; Parham, Taslimi; Ilhami, Gulcin (Wiley, 2018-03)In this paper, the in vivo effects of some antibiotics including cefazolin, cefuroxime, and cefoperazon, on the activity of the carbonic anhydrase enzyme (CA) in heart, brain, eye, liver, and kidney tissues of rats were ... -
The Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey
Umit M., Kocyigit; Sevgi Durna, Dastan; Taslimi, Parham; Taner, Dastan; Ilhami, Gulcin (Wiley, 2018-01)In this study, carbonic anhydrase (CA) enzyme was purified and characterized from blood samples of Kangal Akkaraman sheep and inhibitory properties on certain antibiotics were examined. CA purification was composed of ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Ilhami, Gulcin; Taslimi, Parham; Dastan, Taner; Koçyiğit, Ümit M.; Dastan, Sevgi Durna; Kılıçkaya, Pakize Cantürk; Çevik, Özge; Koparır, Metin; Orek, Cahit; Çetin, Ahmet (Wiley, 2017-11)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
Ilhami, Gulcin; Taslimi, Parham; Öztaşkın, Necla; Göksu, Süleyman; Maraş, Ahmet (Elsevier, 2017-10)In this study, a series of novel bromophenols were synthesized from benzoic acids and methoxylated bromophenols. The synthesized compounds were evaluated by using different bioanalytical antioxidant assays including ... -
Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes
Yakup, Sari; Aydin, Aktas; Taslimi, Parham; Yetkin, Gok,; Ilhami, Gulcin (Wiley, 2018-01)The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted ... -
Novel NHC precursors: synthesis, characterization, and carbonic anhydrase and acetylcholinesterase inhibitory properties
Aydin, Aktas; Taslimi, Parham; Ilhami, Gulcin; Yetkin, Gok (Wiley, 2017-06)Three series of imidazolidinium ligands (NHC precursors) substituted with 4-vinylbenzyl, 2-methyl-1,4-benzodioxane, and N-propylphthalimide were synthesized. N-Heterocyclic carbene (NHC) precursors were prepared from ... -
Sulfonamide inhibitors: a patent review 2013-present
Ilhami, Gulcin; Taslimi, Parham (Expert Opinion on Therapeutic Patents, 2018)Introduction: Sulfonamide compounds are significant class of synthetic bacteriostatic antibiotics still which used today for the therapy of bacterial infections and those caused by other microorganisms. They are also known ... -
Synthesis and bioactivity of several new hetaryl sulfonamides
Parham, Taslimi; Afsun, Sujayev; Sevgi, Mamedova; Pinar, Kalin; Ilhami, Gulcin; Nastaran, Sadeghian; Sukru, Beydemir; O. Irfan, Kufrevioglu; Saleh H., Alwasel; Vagif, Farzaliyev; Sabir, Mamedov (Informa, 2017)1-(4-Methylsulfonyl)-2-thione-4-aryl-5-Z-6-methyl and oxyalkyl-imidazoles were synthesized from different tetrahydropyrimidinethiones and aryl sulfonyl chloride. These compunds were tested for metal chelating effects and ... -
Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
Ilhami, Gulcin; Malahat, Abbasova; Taslimi, Parham; Zubeyir, Huyut; Leyla, Safarova; Afsun, Sujayev; Vagif, Farzaliyev; Sukru, Beydemir; Saleh H., Alwasel; Claudiu T., Supuran (Informa, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. Therefore, the reactions of aminomethylation and alkoxymethylation of ... -
Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity
Serdar, Burmaoglu; Ali O., Yilmaz; Taslimi, Parham; Oztekin, Algul; Deryanur, Kilic; Ilhami, Gulcin (Wiley, 2018-02)A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase ... -
Synthesis and carbonic anhydrase inhibition of tetrabromo chalcone derivatives
Ilhami, Gulcin; Koçyiğit, Ümit M.; Budak, Yakup; Fikret, Eligüzel; Taslimi, Parham; Kılıç, Deryanur; Ceylan, Mustafa (Wiley, 2017-12)In the present study, human carbonic anhydrase (hCA) enzyme was purified and characterized from fresh blood human red cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity gel chromatography. Secondly, a series of new ...