Konu "Docking" için Biyoteknoloji Bölümü Makale Koleksiyonu listeleme

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Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases

Kuzu, Burak; Tan, Meltem; Taslimi, Parham; Gülçin, İlhami; Taşpınar, Mehmet; Menges, Nurettin (Bioorganic Chemistry, 2019-01-24)

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the ...
Synthesis, molecular modeling, and biological evaluation of 4-[5-aryl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl] benzenesulfonamides toward acetylcholinesterase, carbonic anhydrase I and II enzymes

Cem, Yamali; Halise Inci, Gul; Abdulilah, Ece; Taslimi, Parham; Ilhami, Gulcin (Wiley, 2018-04)

In this study, 4-[5-aryl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl] benzenesulfonamides were synthesized, and inhibition effects on AChE, hCA I, and hCA II were evaluated. K-i values of the compounds toward hCA I were ...