Konu "SAR" için Biyoteknoloji Bölümü Makale Koleksiyonu listeleme

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Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases

Kuzu, Burak; Tan, Meltem; Taslimi, Parham; Gülçin, İlhami; Taşpınar, Mehmet; Menges, Nurettin (Bioorganic Chemistry, 2019-01-24)

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the ...
Synthesis, characterization, and SAR of arylated indenoquinoline‐based cholinesterase and carbonic anhydrase inhibitors

Ekiz, Makbule; Tutar, Ahmet; Ökten, Salih; Bütün, Burcu; Koçyiğit, Ümit M.; Taslimi, Parham; Topçu, Gülaçtı (Wiley, 2018-09)

We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ...