Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials
Özet
Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and
practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa,
Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion
method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant.
It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing
oxypropanolamine derivatives were also effective inhibitors against α-glycosidase, cytosolic carbonic anhydrase
I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with Ki values in the range
of 0.80 ± 0.24–3.52 ± 1.01 µM for hCA I, 1.08 ± 0.15–3.64 ± 0.92 µM for hCA II, 5.18 ±
0.84–12.46 ± 2.08 µM for α-glycosidase, and 11.33 ± 2.83–32.81 ± 9.73 µM for AChE, respectively
