Browsing Biyoteknoloji Bölümü Makale Koleksiyonu by Author "Gulçin, İlhami"
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Aminopyrazole‐substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties
Güzel, Emre; Koçyiğit, Ümit M.; Arslan, Barış S.; Ataş, Mehmet; Taslimi, Parham; Gökalp, Faik; Nebioğlu, Mehmet; Şişman, İlkay; Gulçin, İlhami (Wiley, 2019-02)The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)eth ... -
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
Gulçin, İlhami; Taslimi, Parham; Aygün, Ayşenur; Sadeghian, Nastaran; Bastem, Enes; Kufrevioglu, Omer Irfan; Turkan, Fikret; Şen, Fatih (Elsevier, 2018-11)The glutathione S-transferase (GST) was purified from fresh blood erythrocytes using affinity column chromatography. Also, alpha-amylase from porcine pancreas and alpha-glycosidase from Saccharomyces cerevisiae were used ... -
Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Demir, Yeliz; Taslimi, Parham; Ozaslan, Muhammet Serhat; Oztaskin, Necla; Çetinkaya, Yasin; Gulçin, İlhami; Beydemir, Şükrü; Goksu, Suleyman (Wiley, 2018-12)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
Kocyigit, Umit M.; Taslimi, Parham; Gulçin, İlhami (Wiley, 2018-08)In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Oztaskin, Necla; Maraş, Ahmet; Gulçin, İlhami; Beydemir, Sukru; Goksu, Suleyman (Elsevier, 2018-11)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach
Caglayan, Cuneyt; Demir, Yeliz; Kucukler, Sefa; Taslimi, Parham; Kandemir, Fatih Mehmet; Gulçin, İlhami (Wiley, 2019-02)In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 ... -
Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition
Yiğit, Beyhan; Kaya, Ruya; Taslimi, Parham; Işık, Yılmaz; Karaman, Muhammet; Yiğit, Murat; Özdemir, İsmail; Gulçin, İlhami (Journal Of Molecular Structure, 2019-03-05)A series of symmetrical imidazolinium chloride salts bearing secondary N-alkyl substituents were synthesized in good yield by the reaction of N,N'-dialkylethane-1,2-diamines and HC(OEt)(3) in the presence of NH4Cl. These ... -
Multiple studies have been recorded on the synthesis and design of multi‐aim anti‐Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer’s disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α‐glycosidase, α‐amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against α‐glycosidase and 3.3 nM against α‐amylase, respectively. In contrast, Ki values were found of 50.96 ± 2.18 μM against AChE and 53.17 ± 4.47 μM against BChE. α‐Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.
Kaya, Ruya; Taslimi, Parham; Naldan, Muhammet Emin; Gulçin, İlhami (Bentham Science, 2019)Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and ... -
Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties
Taslimi, Parham; Osmanova, Sabiya; Caglayan, Cuneyt; Turkan, Fikret; Sardarova, Sabira; Farzaliyev, Vagif; Sujayev, Afsun; Sadeghian, Nastaran; Gulçin, İlhami (Wiley, 2018-09)The thiolation reaction was carried out in a benzene solution at 80 degrees C and p-substituted ketones and mercaptoacetic acid in a molar ratio (1:4) of in the presence of a catalytic amount of toluene sulfonic acids. The ... -
Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials
Genç Bilgiçli, Hayriye; Kestane, Ali; Taslimi, Parham; Karabay, Oguz; Bytyqi-Damoni, Arlinda; Zengin, Mustafa; Gulçin, İlhami (Elsevier, 2019-04-16)Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia ... -
Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors
Turkan, Fikret; Cetin, Adnan; Taslimi, Parham; Gulçin, İlhami (Wiley, 2018-10)A series of substituteed pyrazol-4-yl-diazene derivatives were found to be effective inhibitors against -glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and ... -
Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects
Cetin, Adnan; Türkan, Fikret; Taslimi, Parham; Gulçin, İlhami (Wiley, 2019-03)Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene ... -
Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on phenylthiourea
Maharramova, Gunel; Taslimi, Parham; Sujayev, Afsun; Farzaliyev, Vagif; Durmaz, Lokman; Gulçin, İlhami (Wiley, 2018-12)In the presence of trifluoroacetic acid, on the basis of three-component condensation of phenylthiourea with its salicylaldehyde and methyl-3-oxobutanoate, an efficient method for the synthesis of 1-(4-(2-hydroxyphenyl)- ... -
Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
Huseynova, Mansura; Taslimi, Parham; Medjidov, Ajdar; Farzaliyev, Vagif; Aliyeva, Mahizar; Gondolova, Gulnar; Şahin, Onur; Yalçın, Bahattin; Sujayev, Afsun; Orman, Efe Baturhan; Özkaya, Ali Rıza; Gulçin, İlhami (Elsevier, 2018-11-15)Cobalt and nickel nitrates form with thiosemicarbazone of glyoxylic acid (H(2)GAT) complexes of empirical composition Co(C3H4N3O2S)(2)center dot 2H(2)O, Ni(C3H4N3O2S)(2)center dot 2H(2)O and Ni(C3H6N3O2S)(2). X-ray diffraction ... -
Synthesis, characterization, molecular docking, and biological activities of novel pyrazoline derivatives
Turkan, Fikret; Cetin, Adnan; Taslimi, Parham; HKaraman, alide S.; Gulçin, İlhami (Wiley, 2019)In this study, synthesis of ethyl 2‐((4‐bromophenyl)diazenyl)‐3‐oxo‐phenylpropanoate 1 was carried out and a series of new 3H‐pyrazol‐3‐ones (P1–7) were synthesized from 1 as well as various hydrazines. The obtained ... -
Synthesis, crystal structure and biological evaluation of spectroscopic characterization of Ni(II) and Co(II) complexes with N‐salicyloil‐N′‐maleoil‐hydrazine as anticholinergic and antidiabetic agents
Gondolova, Gulnar; Taslimi, Parham; Medjidov, Ajdar; Farzaliyev, Vagif; Sujayev, Afsun; Huseynova, Mansura; Şahin, Onur; Yalçın, Bahattin; Turkan, Fikret; Gulçin, İlhami (Wiley, 2018-09)[Ni(C11H9N2O5)(2)(H2O)(2)]center dot 3(C3H7NO) (1) and [Co(C11H9N2O5)(2)(H2O)(2)]center dot 3(C3H7NO) (2) are synthesized and characterized by elemental analysis, FT-IR spectra, magnetic susceptibility, and thermal analysis. ... -
Synthesis, crystal structure, and biological evaluation of optically active 2‐amino‐4‐aryl‐7,7‐dimethyl‐5‐oxo‐5,6,7,8‐tetrahydro‐4H‐chromen‐3‐carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentials
Maharramov, Abel; Kaya, Ruya; Taslimi, Parham; Kurbanova, Malahat; Sadigova, Arzu; Farzaliyev, Vagif; Sujayev, Afsun; Gulçin, İlhami (Wiley, 2019-02)In the presence of chiral organic catalysts, the optically active 4H-chromine was synthesized from the multicomponent condensation of 5,5-dimethylcyclohexane-1,3-dione with malononitrile and methylene-active compound, and ...